METHOD FOR MANUFACTURING 3-HALOMETHYL-3-CEPHEM

摘要

PURPOSE: Provided is a method for manufacturing nitrobenzyl 7-phenoxyacet amide-3-halomethyl-3-cephem-4-carboxylate of the formula(I) with high purity and yield. The compound of the formula(I) is useful as an intermediate in manufacturing cepha based antibiotics. CONSTITUTION: A method for manufacturing a compound of the formula(I), nitrobenzyl 7-phenoxyacet amide-3-halomethyl-3-cephem-4-carboxylate, is characterized by reacting a compound of the formula(II) with a halogenating agent in the presence of 4-pyrrolidino pyridine of the formula(III), wherein X is a halogen atom.