| 摘要 |
A gene, designated ATM, mutations of which cause ataxia-telangiectasia (A-T), that has been purified, isolated, and sequenced as well as mutations of the gene and the genomic organization of the gene. A method for identifying carriers of the defective A-T gene in a population and effective A-T gene products. The detection of A-T mutation carriers for use in determining cancer predisposition and radiation sensitivity so that carrier exposure to radiation can be properly monitored and avoided.
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