发明名称 |
G protein coupled receptor protein, production and use thereof |
摘要 |
Rabbit gastropyrolic part smooth muscle-derived G protein coupled receptor proteins, partial peptides thereof; and DNAs containing said protein or partial peptide-encoding DNA are provided. The receptor protein and the DNA coding for said protein can be used for {circle over (1 determination of ligands; {circle over (2 acquisition of antibody and antiserum; {circle over (3 construction of expression system for of a recombinant type receptor protein; {circle over (4 development of the receptor binding assay system using said expression system and screening of the candidate compounds for pharmaceuticals; {circle over (5 conducting a drug design based upon a comparison with structurally analogous ligands and receptors; {circle over (6 preparation of probes and PCR primers for a gene diagnosis; {circle over (7 preparation of transgenic animals; and {circle over (8 preparation of model patient animals deficient in the receptor protein DNA. Elucidation of the structure and property of the G protein coupled receptor is particularly related to the development of unique pharmaceuticals which act on such a system.
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申请公布号 |
US2003118586(A1) |
申请公布日期 |
2003.06.26 |
申请号 |
US20020184426 |
申请日期 |
2002.06.28 |
申请人 |
HINUMA SHUJI;FUJII RYO;KAWAMATA YUJI |
发明人 |
HINUMA SHUJI;FUJII RYO;KAWAMATA YUJI |
分类号 |
C07K14/705;(IPC1-7):A61K39/395;G01N33/53;C07H21/04;C12P21/02;C12N5/06 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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