发明名称 |
Novel forms of prostate specific antigen (PSA) specific for benign prostatic hyperplasia (BPH) and methods of using such |
摘要 |
A substantially pure and isolated novel form of prostate specific antigen (PSA) is provided. The novel form of PSA of the present invention comprises at least one clip at Lys 182 of the amino acid sequence of a mature form of PSA. Preferably, the novel form of PSA additionally comprises one or more clips at a location selected from a group consisting of Ile 1, Lys 145, and Lys 146. More preferably, the form of PSA contains at least two clips at Lys 145 and Lys 182 of the amino acid sequence of a mature form of PSA. The novel forms of PSA exist at an elevated level in patients suspected of having benign prostatic hyperplasia (BPH) and therefore may be used as a serum mark or an immunohistological marker to help distinguish BPH from prostate cancer. Antibodies recognizing the novel forms of PSA and immunoassays that detect and determine the novel forms of PSA of the present invention in a sample are also provided. Further provided are a kit and a method for detecting the novel forms of PSA for aiding in the differentiation of prostate cancer from BPH.
|
申请公布号 |
US2003119033(A1) |
申请公布日期 |
2003.06.26 |
申请号 |
US20020252862 |
申请日期 |
2002.09.24 |
申请人 |
HYBRITECH INCORPORATED AND BAYLOR COLLEGE OF MEDICINE |
发明人 |
MIKOLAJCZYK STEPHEN D.;WANG TANG JANG;RITTENHOUSE HARRY G.;WOLFERT ROBERT L.;SLAWIN KEVIN |
分类号 |
G01N33/573;A61K35/12;A61K48/00;C07K16/40;C12N5/10;C12N9/64;C12N15/02;C12P21/08;C12R1/91;G01N33/577;(IPC1-7):C12Q1/68;G01N33/574;C07H21/04;C12N9/00;C12P21/02;C12N5/06;C07K16/30 |
主分类号 |
G01N33/573 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|