Inhibition therapy for septic shock with mutant CD14

摘要

Described are methods and novel therapeutics for treating CD14-mediated diseases, especially sepsis and septic shock. The methods and compounds are founded on principles of structural mimicry of the innate compound. Changes to the innate compound are described that result in unexpected properties useful for blocking or ameliorating the harmful effects of systemic infection by microbes. Diagnostic applications and product-by-process claims are also contemplated based on the same underlying principle and observation.