| 发明名称 |
SUBSTITUTED HYDROXYETHYLAMINES |
| 摘要 |
Disclosed are compounds of the formula (I) and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R3, R4, R5, RN, and RC are defined herein. These compounds interact with and inhibit the activity of the enzyme beta- secretase. These compounds are therefore useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions and methods of treatment of these diseases are also disclosed.
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| 申请公布号 |
CA2469622(A1) |
申请公布日期 |
2003.06.19 |
| 申请号 |
CA20022469622 |
申请日期 |
2002.12.06 |
| 申请人 |
ELAN PHARMACEUTICALS, INC.;PHARMACIA & UPJOHN COMPANY |
发明人 |
WARPEHOSKI, MARTHA;TENBRINK, RUTH;MAILLARD, MICHEL |
| 分类号 |
A61K31/165;A61K31/166;A61K31/421;A61P9/00;A61P25/16;A61P25/28;A61P43/00;C07C217/64;C07C233/36;C07C233/40;C07C233/66;C07C233/78;C07C271/16;C07C271/20;C07C271/28;C07C309/74;C07C311/09;C07C311/13;C07C323/41;C07C323/42;C07D263/32;C07D263/48;C07D303/36;(IPC1-7):C07C215/18;C07C215/10;C07D263/30;C07C323/38;C07C217/58 |
主分类号 |
A61K31/165 |
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