发明名称 |
Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms |
摘要 |
The present invention relates to a novel sulfonation of an intermediate of zonisamide. The sulfonation processes using chlorosulfonic acid as well as acetic anhydride and sulfuric acid in an organic solvent are disclosed. Crystalline forms of benzisoxazole methane sulfonic acid (BOS-H) and its salts (BOS-Na, BOS-Ca, and BOS-Ba) and their novel preparation processes are disclosed.
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申请公布号 |
US2003114682(A1) |
申请公布日期 |
2003.06.19 |
申请号 |
US20020233190 |
申请日期 |
2002.08.29 |
申请人 |
NIDAM TAMAR;MENDELOVICI MARIOARA;SCHWARTZ EDUARD;WIZEL SHLOMIT |
发明人 |
NIDAM TAMAR;MENDELOVICI MARIOARA;SCHWARTZ EDUARD;WIZEL SHLOMIT |
分类号 |
C07D261/20;(IPC1-7):C07D261/20 |
主分类号 |
C07D261/20 |
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