发明名称 |
Assay of YKL-40 as a marker for cancer |
摘要 |
This invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically significant levels of YKL-40 protein and/or YKL-40 peptide are present in a biological sample. The method can be used, for example, to identify the presence of inflammatory or degenerative joint disease or degeneration of connective tissue in organs. Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers. The figure shows the elution position of substantially pure serum YKL-40 on a gel filtration column.
|
申请公布号 |
US6579684(B2) |
申请公布日期 |
2003.06.17 |
申请号 |
US19990262213 |
申请日期 |
1999.03.04 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PRICE PAUL A.;JOHANSEN JULIA S. |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P29/00;A61P43/00;C07K14/47;C07K16/18;G01N33/564;G01N33/574;G01N33/577;G01N33/68;(IPC1-7):G01N33/574 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|