PROPANOLAMINOMETHYLTETRALINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

摘要

The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a -S(O)z(C1-C4)Alk wherein z is 0, 1 or 2, a -NHSO2(C1-C4)Alk, -SO2NH(C1-C4)Alk, -NHSO2-(C1-C4) Alk-phenyl or -NHSO2-phenyl group, said phenyl capable of bearing a halogen atom, a (C1-C4) Alk group or a (C1-C6)alkoxy group; R1 represents a hydrogen atom or a -(C1-C4)Alk, -CO(C1C4)Alk, -(C1-C4)Alk-phenyl or -CO-phenyl group, said phenyl capable of bearing a halogen atom or a -(C1-C4)Alk or (C1-C6)alkoxy group; R2 is a hydrogen atom, a -SO2(C1-C4)Alk, -SO2-(C1-C4)Alk-phenyl, -SO2-phenyl group, or a -(C1-C4)Alk group; X completes a saturated or unsaturated cycle of 5 to 8 atoms, capable of bearing one or two -(C1-C4) Alk groups and/or two carbonyl groups; R3 and R'3 represent each independently a hydrogen or halogen atom, a -(C1-C6)Alk, hydroxy, -CN, -(C1-C6)alkoxy, -COR4 or Y-CR8R9-COR4 group; Y represents O or CH2; R4 represents a hydroxy, (C1-C6) alkoxy or -NR5R6 group; R5 and R6 independently represent a hydrogen atom, a -(C1-C4)Alk, group, aryl or heteroaryl optionally substituted by a R7 group, aralkyl or heteroaralkyl optionally substituted by a R7 group; or R5 and R6, with the nitrogen atom which bears them, form a saturated or unsaturated cycle of 5 to 7 atoms optionally substituted by a R7 group; and R7 represents a hydrogen or halogen atom, a hydroxy, -(C1-C4)Alk, -(C1-C6)alkoxy, -NH(C1-C4)Alk, -N(C1-C4)Alk2, -COO(C1-C4)Alk, aralkyl or heteroaryl group; R8 and R9 independently represent a hydrogen atom or a -(C1-C4)Alk group; their salts or solvates, the pharmaceutical compositions containing them, a method for preparing them and synthesis intermediates.