METHOD AND REAGENTS FOR TREATMENT OF SKIN DISORDERS BY MODULATING THE NOTCH PATHWAY

摘要

In one embodiment, the invention provides a method of inducing differentiation of an epithelial cell. In another embodiment, the invention provides a method for inducing formation of a barrier within epithelium. In another embodiment, the invention provides a method for producing diferentiated epidermis. In another embodiment, the invention provides a method of assaying for genetic prepensity of a patient to develop a disorder associated with epithelial barrier formation. In another embodiment, the invention provides a diagnostic test to determine the expression levels of Notch ligands. In another embodiment, the invention provides a method of preventing or retarding the progression of a benign or malignant disorder in skin.