发明名称 |
TREATMENT OF DISEASE STATES CHARACTERIZED BY EXCESSIVE OR INAPPROPRIATE ANGIOGENESIS |
摘要 |
Disclosed is a method for reducing excessive or inappropriate neovasculature, including nevasculature in the eye which interferes with or has potential to interfere with vision, for example, that associated with diabetic retinopathy or macular degeneration. The regions of the neovasculature are targeted with nanoparticles, including metal nanoshells, which are then irradiated, preferably with a laser, to heat them and ablate the undesired blood vessels. The nanoparticles are targeted to the neovasculature by linking them with a targeting agent, including, for example, antibodies, antibody fragments, receptor biding proteins or other proteins or molecules including growth factors. |
申请公布号 |
WO03047633(A2) |
申请公布日期 |
2003.06.12 |
申请号 |
WO2002US38695 |
申请日期 |
2002.12.03 |
申请人 |
NANOSPECTRA BIOSCIENCES, INC. |
发明人 |
WEST, JENNIFER, L.;PAYNE, J., DONALD |
分类号 |
A61K9/10;A61F9/007;A61K9/14;A61K9/51;A61K33/24;A61K33/44;A61K39/395;A61K41/00;A61K47/20;A61K47/34;A61K47/42;A61K47/48;A61N5/06;A61P17/02;A61P27/02;A61P35/00;A61P43/00 |
主分类号 |
A61K9/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|