| 发明名称 |
Inhibitors of endothelin-1 synthesis |
| 摘要 |
Sequences in human preproendothelin-1 mRNA are described against which antisense oligonucleotides can be used to inhibit the synthesis of endothelin-1. This inhibition of endothelin-1 synthesis may be used to treat diseases where excess production of endothelin-1 is an underlying cause of the symptoms.
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| 申请公布号 |
US2003109480(A1) |
申请公布日期 |
2003.06.12 |
| 申请号 |
US20020295942 |
申请日期 |
2002.11.18 |
| 申请人 |
UNITED THERAPEUTICS CORPORATION |
发明人 |
CORDER ROGER;SMITH ADRIAN P.L.;HIGENBOTTAM TIMOTHY W.;ROTHBLATT MARTINE;VANE SIR JOHN;LEES DELPHINE DOMINIQUE MARTHE |
| 分类号 |
A61K38/00;A61P11/00;A61P11/06;C12N15/113;(IPC1-7):A61K48/00;C07H21/04 |
主分类号 |
A61K38/00 |
| 代理机构 |
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