Suizidgensysteme

摘要

The invention relates to suicide gene systems, in particular those comprising Herpes simplex virus type 1 thymidine kinase (HSV-tk), cytochrome P450 isoenzyme 4B1 (cyp4B1) or human folylpolyglutamate synthase (fpgs), in particular the above in combination with each other and corresponding DNA sections, vectors, infectious particles, transfected cells and medicaments containing the above. The invention further relates to the use of objects and suicide genes, also in combination with activated agents for the treatment of leukemia or graft-host reactions for example in donor lymphocytes.