发明名称 |
Isoforms of mouse serotonin 5-HT2c receptor |
摘要 |
The invention includes mouse serotonin 5-HT2c receptor isoforms having amino acid replacements at one or more positions of the natural mouse serotonin 5-HT2c receptor polypeptide sequence, specifically at one or more of positions 157, 159 and 161. The polypeptides are useful for identifying ligands which bind with the serotonin 5-HT2c receptor and modulators of the serotonin 5-HT2c, and for identifying drugs with affinity for 5-HT2 receptors which are used to treat schizophrenia, Parkinsonism, and anxiety disorders.
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申请公布号 |
US2003109685(A1) |
申请公布日期 |
2003.06.12 |
申请号 |
US20020280858 |
申请日期 |
2002.12.17 |
申请人 |
FONG TONG M.;LIU JIE;VAN DER PLOEG LEONARDUS H.T. |
发明人 |
FONG TONG M.;LIU JIE;VAN DER PLOEG LEONARDUS H.T. |
分类号 |
C12N15/09;A61K38/00;C07K14/705;C07K14/715;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12Q1/02;C12Q1/68;(IPC1-7):C07K14/575;C12P21/02;C12N5/06;C07H21/04;A61K38/24 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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