发明名称 |
POLYMERGEBUNDENE CAMPTOTHECIN-DERIVATE |
摘要 |
PCT No. PCT/EP94/03154 Sec. 371 Date Jun. 8, 1995 Sec. 102(e) Date Jun. 8, 1995 PCT Filed Sep. 21, 1994 PCT Pub. No. WO95/10304 PCT Pub. Date Apr. 20, 1995A polymeric conjugate consists essentially of: (i) from 60 to 99 mol % of N-(2-hydroxypropyl) methacryloylamide units represented by formula 1: ethacryloylglycyl-aminoacyl) camptothecin units represented by formula 2 <IMAGE> 2 wherein [A] is a spacer group having respective terminal amino and carbonyl groups which are separated by at least three atoms and O-CPT represents a residue of a camptothecin, the C-20 hydroxy group of the camptothecin being linked to the terminal carbonyl group of the spacer group [A]; and (iii) from 0 to 10 mol % of N-methacryloylglycine or N-(2-hydroxy-propyl)methacryloylglycinamide units represented by formula 3: <IMAGE> 3 wherein Z represents hydroxy or a residue of formula -NH-CH2-CH(OH)-CH3. |
申请公布号 |
DE69432627(D1) |
申请公布日期 |
2003.06.12 |
申请号 |
DE1994632627 |
申请日期 |
1994.09.21 |
申请人 |
PHARMACIA ITALIA S.P.A., MAILAND/MILANO |
发明人 |
ANGELUCCI, FRANCESCO;SUARATO, ANTONINO |
分类号 |
A61K47/48;C08F220/36;C08F220/56;C08F220/60;(IPC1-7):A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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