The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarily determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
申请公布号
WO03046204(A2)
申请公布日期
2003.06.05
申请号
WO2002US38147
申请日期
2002.11.26
申请人
CELL-MATRIX, INC.;WATKING, JEFFRY, D.;HUSE, WILLIAM, D.;TANG, YING;BROEK, DANIEL;BROOKS, PETER C.
发明人
WATKING, JEFFRY, D.;HUSE, WILLIAM, D.;TANG, YING;BROEK, DANIEL;BROOKS, PETER C.