发明名称 |
Micropatterning surfaces of polymeric substrates |
摘要 |
The present invention is directed to an article which has a pattern of biologically active molecules stably adsorbed directly onto a polymeric substrate. The present invention also provides methods for preparing a pattern of biologically active molecules on the surface of a polymeric substrate, which include exposing a polymeric substrate to conditions that increase the polarity of a surface of the polymeric substrate, and contacting that surface with a stamp that includes a micron-sized pattern coated with biologically active molecules. The present invention also provides a method to spatially modulate the growth of a cell which includes contacting a cell with an article of the present invention for a time and under conditions sufficient to adhere the cell to the biologically active molecules and to grow the cell along the micron-sized pattern of biologically active molecules on the polymeric substrate.
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申请公布号 |
US2003104614(A1) |
申请公布日期 |
2003.06.05 |
申请号 |
US20020215435 |
申请日期 |
2002.08.09 |
申请人 |
UHRICH KATHRYN E.;BUETTNER HELEN M.;SCHMALENBERG KRISTINE |
发明人 |
UHRICH KATHRYN E.;BUETTNER HELEN M.;SCHMALENBERG KRISTINE |
分类号 |
A61L27/34;A61L31/10;C12N5/02;(IPC1-7):C12N5/02;C12M1/00 |
主分类号 |
A61L27/34 |
代理机构 |
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代理人 |
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