EXPRESSION OF POLYPEPTIDES IN ROD OUTER SEGMENT MEMBRANES

摘要

The invention provides a transgene construct comprising a nucleic acid encoding a photoreceptor specific regulatory sequence, a membrane-associated polypeptide, and a photoreceptor outer segment targeting signal. The inventi on also provides a polypeptide encoded by the construct, a host cell comprising the construct, and a transgenic vertebrate comprising the construct.