发明名称 |
Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists |
摘要 |
Proliferation of retinal pigment epithelium following surgery or trauma or resulting in ocular diseases associated with choroidal neovascularization, such as age related macular degeneration and histoplasmosis syndrome, is prevented by contacting retinal pigment epithelium cells with a therapeutic amount of a retinoic acid receptor (RAR agonist, preferably one with specific activity for retinoic acid receptors. Preferably the RAR agonist is also a potent antagonist of AP1-dependent gene expression. Alternatively, the proliferation of retinal pigment epithelium is ameliorated with a therapeutic amount of an AP-1 antagonist, alone or in combination with an RAR agonist. The drug can be administered by bolus injection into the vitreous cavity using a dosage from about 50 to 150 mug. Or by slow release from liposomes or an oil tamponade injected into the vitreous cavity. Formulations for preventing proliferation of retinal pigment epithelium are also provided.
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申请公布号 |
US6573271(B2) |
申请公布日期 |
2003.06.03 |
申请号 |
US20010954686 |
申请日期 |
2001.09.11 |
申请人 |
JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE;THE ALLERGAN |
发明人 |
CAMPOCHIARO PETER A.;WHEELER LARRY A.;CHANDRARATNA ROSHANTHA A.;NAGPAL SUNIL;DE JUAN, JR. EUGENE |
分类号 |
A61K9/127;A61K9/14;A61K31/19;A61K31/192;A61K31/455;A61K31/465;A61K45/00;A61K47/24;A61P27/02;A61P35/00;(IPC1-7):A61K31/435 |
主分类号 |
A61K9/127 |
代理机构 |
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地址 |
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