发明名称 |
MATRIX FOR THE PRODUCTION OF TISSUE ENGINEERED LIGAMENTS, TENDONS AND OTHER TISSUE |
摘要 |
<p>The present invention provides a novel silk-fiber-based matrix having a wire - rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex-vivo for implantation into a recipient in nee d thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form t he ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.</p> |
申请公布号 |
CA2467195(A1) |
申请公布日期 |
2003.05.30 |
申请号 |
CA20022467195 |
申请日期 |
2002.11.15 |
申请人 |
TUFTS UNIVERSITY |
发明人 |
HORAN, REBECCA L.;KAPLAN, DAVID L.;ALTMAN, GREGORY H. |
分类号 |
C12M1/00;A61F2/08;A61K35/12;A61K38/17;A61L27/00;A61L27/22;A61L27/38;B32B27/04;C12M3/00;C12N5/00;C12N5/02;C12N5/071;C12N5/10;(IPC1-7):C12N5/06;C12N5/08;C12N11/02;A01N63/00;A61F2/00 |
主分类号 |
C12M1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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