发明名称 |
JFY1 PROTEIN INDUCES RAPID APOPTOSIS |
摘要 |
Through global profiling of genes that were expressed soon after p53 expression, we identified a gene termed (JFY1). The protein encoded by (JFY1) was found to be exclusively mitochondrial and to bind to Bcl-2 and Bcl-XL through a BH3 domain. Exogenous expression of (JFY1) resulted in an extremely rapid and profound apoptosis that occurred much earlier than that resulting from exogenous expression of p53. Based on its unique expression patterns, p53-dependence, and biochemical properties, (JFY1) is likely to be a direct mediator of p53-associated apoptosis. |
申请公布号 |
WO02064790(A3) |
申请公布日期 |
2003.05.30 |
申请号 |
WO2001US47455 |
申请日期 |
2001.12.12 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;YU, JIAN;KINZLER, KENNETH, W.;VOGELSTEIN, BERT |
发明人 |
YU, JIAN;KINZLER, KENNETH, W.;VOGELSTEIN, BERT |
分类号 |
A61K31/7088;A61K48/00;A61P35/00;C07K14/47;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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