| 摘要 |
<p>The invention relates to a novel tiopeptidic compound which has a determined structure and which is known as radamicine (1). The invention also relates to a method of producing radamacine and the use of said radamacine and the salts and derivatives thereof, in all their stereoisomeric and tautomeric forms, as an inducer of the tipA promoter. The compound thus described is obtained from Streptomyces sp RSP9 culture and differs from other tiopeptidic compounds in that it is a powerful inducer of the tipA promoter. Moreover, the radamicine compound differs from all inducers of the promoter hitherto described in that it does not present an antibiotic activity against any of the Gram-positive micro-organisms sensitive to all of the other tiopeptidic compounds which have been tested before now (Micrococcus luteus, Staphylococcus aureus, Bacillus subtilis, etc).</p> |
