发明名称 |
CD19-SPECIFIC REDIRECTED IMMUNE CELLS |
摘要 |
Genetically engineered, CD19-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CD19, an intracellular signaling domain, and a transmembrane domain. Use of such cells for cellular immunotherapy of CD19<+> malignancies and for abrogating any untoward B cell function. In one embodiment, the immune cell is a T cell and the cell surface protein is a single chain svFvFc: zeta receptor where scFc designates the VH and VL chains of a single chain monoclonal antibody to CD19, Fc represents at least part of a constant region of an IgG1, and zeta represents the intracellular signaling domain of the zeta chain of human CD3. The extracellular domain scFvFc and the intracellular domain zeta are linked by a transmembrane domain such as the transmembrane domain of CD4. A method of making a redirected T cell expressing a chimeric T cell receptor by electroportion using naked DNA encoding the receptor. |
申请公布号 |
WO02077029(A3) |
申请公布日期 |
2003.05.30 |
申请号 |
WO2001US42997 |
申请日期 |
2001.11.07 |
申请人 |
CITY OF HOPE;JENSEN, MICHAEL, C.;FORMAN, STEPHEN;RAUBITSCHEK, ANDREW |
发明人 |
JENSEN, MICHAEL, C.;FORMAN, STEPHEN;RAUBITSCHEK, ANDREW |
分类号 |
C12N15/09;A61K35/14;A61K35/28;A61K38/00;A61K38/20;A61K39/395;A61P35/00;A61P35/02;A61P37/02;A61P37/06;C07K14/705;C07K14/725;C07K16/28;C12N5/0783;C12N5/10;C12N15/12 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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