发明名称 |
Pharmaceutical excipient having improved compressibility |
摘要 |
A method of preparing an excipient composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and a surfactant, said surfactant being present in an amount from about 0.1% to about 0.5% by weight of the wet-cake microcrystalline cellulose; and drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of microcrystalline cellulose in intimate association with said surfactant. The excipient may be mixed with a therapeutically active agent to form a dosage form. The surfactant provides a hydrophobic boundary at cellulose surfaces, and improves absorptivity of the therapeutically active agent.
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申请公布号 |
US2003099702(A1) |
申请公布日期 |
2003.05.29 |
申请号 |
US20020145563 |
申请日期 |
2002.05.14 |
申请人 |
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发明人 |
STANIFORTH JOHN N.;HUNTER EDWARD A.;SHERWOOD BOB E. |
分类号 |
A61K9/20;(IPC1-7):A61K9/20 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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