Method of administration of a gene of interest to a vascular tissue

摘要

The invention relates to a method for delivering a gene of interest to a vascular tissue comprising the following steps: (1) inserting into said vascular tissue a catheter in fluid communication with an inflatable balloon which is formed from a microporous membrane; and (2) delivering to said vascular tissue through the catheter a solution containing a vector comprising a gene of interest. This method can be used for the treatment of cardiovascular diseases, including hyperproliferative vascular disorders (such as restenosis), ischemic diseases (such as peripheral artery or coronary artery diseases), and atherosclerosis.