USE OF INHIBITORS OF FATTY ACID SYNTHESIS FOR TREATING CANCER

摘要

Fatty acid synthase (FAS) is overexpressed in carcinomas with poor prognosis , but little FAS expression is identified in normal tissues. Inhibition of fatty acid synthesis is selectively toxic t o carcinoma cells, while normal cells with low FAS activity are resistant. This invention provides a method of treating cancer patients where fatty acid synthesis by cells of the patient's tumor is inhibited with resultant interruption of the disease process.