Inhibition of betaarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia

摘要

The present invention provides a betaarrestin knockout mouse useful for screening compounds for efficacy in controlling pain, methods of controlling pain in subjects by inhibiting binding of betaarrestin to phosphorylated mu opioid receptors, and methods of screening a compound for activity in potentiating mu opioid receptor agonist activity (e.g., morphine activity) by determining whether or not said compound inhibits betaarrestin binding to a phosphorylated mu opioid receptor.