| 摘要 |
<p>A promoter of a mammalian MRP2 gene which binds to PXR/RXR, CAR/RXR or FXR/RXR heterodimers is provided. Also provided are methods for modulating expression of MRP2 mRNA in mammalian cells and methods for promoting excretion of conjugated toxic agents from the liver into bile via ligands for FXR, PXR or CAR.</p> |
