| 摘要 |
PURPOSE: An oral preparation containing omeprazole is provided which is pharmaceutically stable by prevention of the loss of activity of omeprazole caused by gastric acid when orally administered and facilitating the absorption thereof into the small intestine, thereby maximizing therapeutic effect. CONSTITUTION: In a method of making an oral preparation, non-volatile minute granules with a particle size of 0.2-0.7 millimeters are first made using starch and sugar, or only sugar. Then, omeprazole or lansoprazole and the salt thereof, and a binder selected from hydroxy propyl methyl cellulose or hydroxy propyl cellulose and derivatives thereof are dissolved or diffused in a solvent containing a mixture of purified water, acetone and ethanol. The resulting solution, and the minute granules are mixed together with talc. The mixture is coated by a protection film to produce a pellet having a diameter of 0.3-2.5 millimeters.
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