Compounds alkylating specific base sequence of DNA and method for synthesizing the same

摘要

The invention provides a compound recognizing the minor group of hydrogen bonds between base pairs and being capable of forming a covalent bond with bases. The inventive compound can recognize a specific nucleotide sequence and can strongly bind to adjacent bases via covalent bonding, to regulate the expression of a DNA with the nucleotide sequence. The invention provides a DNA alkylating agent comprising a compound represented by the general formula I:wherein R represents a lower amyl group or a polyamide group; and X represents nitrogen or CH.