MODULATION

摘要

A method of treatment is described. The method comprises administering to a subject in need of same an agent, wherein said agent is capable of causing a dopaminergic neuron to enter bursting mode and/or of preventing it from leaving bursting mode. In a preferred aspect the said agent modulates: a T-type channel and/or an SK (preferably SK3) channel and/or the coupling of a T-type channel with an SK (preferably SK3) channel.