Compounds of formula <IMAGE> or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.
申请公布号
DE69627380(D1)
申请公布日期
2003.05.15
申请号
DE1996627380
申请日期
1996.11.13
申请人
ABBOTT LABORATORIES, ABBOTT PARK
发明人
FESIK, W.;SUMMERS, B.;DAVIDSEN, K.;SHEPPARD, S.;STEINMAN, H.;CARRERA, M.;FLORJANCIC, ALAN;HOLMS, H.