PROCESS OF OBTAINING COLLOIDAL DISPERSIONS OF AMPHOTERCIN B; COMPOUNDS BASED ON AMPHOTHERICINE B FOR ENTERAL, PARAENTERAL AND TOPICAL USE; USE OF THESE COMPOUNDS IN THE TREATMENT OF SYSTEMIC MYCOSES AND PARASITIC INFECTIONS

摘要

The present invention has as its objective the process of obtaining of compositions containing amphotericin B in its superaggregate from capable of treating infections caused by fungi, parasites and other agents susceptible to this antibiotic. The invention covers the stable formulation of amphotericin B in its superaggregate form in presence of sodium deoxycholate, freeze-dried (lyophilized) and sterile, uniting the requirements for an injectable formulation for use enteral, parenteral or topical, with reduced toxicity in comparison to the conventional forms that transmit amphotericin B.