The invention relates to a dosage form which releases at least two different active agents in a controlled manner. Particular configurations of the invention include a dosage form that provides therapeutically effective levels of a first active agent and a second active agent in a mammal for an extended period of time following oral administration. According to the invention, an osmotic device is provided which comprises a double-layer core. The aforementioned osmotic device provides dual controlled release of both drugs from the core. The core layers are stacked in an essentially concentric and eccentric manner.
申请公布号
WO03039519(A2)
申请公布日期
2003.05.15
申请号
WO2002CR00006
申请日期
2002.11.06
申请人
OSMOTICA COSTA RICA SOCIEDAD ANONIMA;VERGEZ, JUAN, A.;RICCI, MARCELO, A.