发明名称 |
DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi |
摘要 |
The invention includes novel fusion nucleic acids encoding fusion polypeptides which when expressed in a filamentous fungus result in the expression of fusion polypeptides. The fusion nucleic acids comprise four nucleic acids which encode a fusion polypeptide comprising first, second, third and fourth amino acid sequences. The first nucleic acid encodes a signal polypeptide functional as a secretory sequence in a first filamentous fungus. The second nucleic acid encodes a secreted polypeptide or functional portion thereof which is normally secreted from the same filamentous fungus or a second filamentous fungus. The third nucleic acid encodes a cleavable linker while the fourth nucleic acid comprises at least two nucleic acids encoding desired polypeptides.
|
申请公布号 |
US2003092131(A1) |
申请公布日期 |
2003.05.15 |
申请号 |
US20010912733 |
申请日期 |
2001.07.23 |
申请人 |
GENENCOR INTERNATIONAL, INC. |
发明人 |
WARD MICHAEL;POWER SCOTT D. |
分类号 |
C12N1/15;C12N15/62;C12N15/80;(IPC1-7):C12Q1/68;C07H21/04;C12P21/04;C07K14/435;C12N5/06 |
主分类号 |
C12N1/15 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|