发明名称 |
PPAR (delta) ACTIVATORS |
摘要 |
<p>Compounds of the general formula (I) or salts thereof and activators of PPAR delta (peroxisome proliferator activated receptor delta ) containing the compounds or the salts as the active ingredient: wherein R<1> and R<2> each are hydrogen, C1-8 alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X<1> and X<2> are each a free valency, oxygen, S(O)p (wherein p is an integer of 0 to 2), C(=O), C(=O)NH, NHC(=O), CH=CH, or the like; Y is optionally substituted C1-8 alkylene; Z is oxygen or sulfur; R<3> and R<4> are each optionally substituted C1-8 alkyl; and R<8> is hydrogen or C1-8 alkyl, with the proviso that when X<1> is a free valency, X<2> is not O or S(O)p, while when X<1> is C(=O)NH, X<2> is not a free valency. <CHEM></p> |
申请公布号 |
EP1310494(A1) |
申请公布日期 |
2003.05.14 |
申请号 |
EP20010955606 |
申请日期 |
2001.08.09 |
申请人 |
NIPPON CHEMIPHAR CO., LTD. |
发明人 |
SAKUMA, SHOGO;ENDO, TSUYOSHI;TENDO, ATSUSHI;TAKAHASHI, TOSHIHIRO;YOSHIDA, SHINICHI;KOBAYASHI, KUNIO;MOCHIZUKI, NOBUTAKA;YAMAKAWA, TOMIO;KANDA, TAKASHI;MASUI, SEIICHIRO |
分类号 |
A61P3/10;A61P5/38;A61P9/00;A61P9/10;A61P19/10;A61P25/28;A61P29/00;A61P35/00;A61P43/00;C07D233/64;C07D233/70;C07D233/88;C07D233/90;C07D263/32;C07D277/24;C07D277/28;C07D277/38;C07D413/04;A61P3/04;A61P3/06;(IPC1-7):C07D263/32;C07D263/48;A61K31/506;A61K31/472;A61K31/443;A61K31/427;A61K31/426;A61K31/422;A61K31/421;A61K31/416;C07D277/26;C07D263/40;C07D417/04;C07D263/34 |
主分类号 |
A61P3/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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