| 摘要 |
The present invention is related to the use of oxindole hydrazide derivative s of formula (I) for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndro me (PCOS). In particular, the present invention is related to the use of oxindo le hydrazide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular of PTP1B, TC-PTP, SHP and GLEPP-1. The prese nt invention is furthermore related to novel oxindole hydrazide derivatives and method of preparation thereof.(I).
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