发明名称 |
Suppression of malignancy utilizing ribonucleotide reductase R1 |
摘要 |
The present invention provides a method of modulating the malignant properties of a cell in a human or other mammal by contacting a neoplastic cell with a growth modulating amount of an expressible nucleic acid sequence for ribonucleotide reductase R1 of the mammal. The present invention also provides and uses a growth modulating amount of the ribonucleotide reductase R1 protein or biologically active peptide to modulate the malignant properties of a cell in a human or other mammal. The method provides for a generally elevated expression of the R1 component of mammalian ribonucleotide reductase. The expressible nucleic acid sequence can be in the form of a vector for gene therapy.
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申请公布号 |
US2003087866(A1) |
申请公布日期 |
2003.05.08 |
申请号 |
US20020223655 |
申请日期 |
2002.08.20 |
申请人 |
GENESENSE TECHNOLOGIES INC. |
发明人 |
WRIGHT JIM A.;YOUNG AIPING H. |
分类号 |
C12N15/09;A61K31/711;A61K38/44;A61K48/00;A61P35/00;C12N5/06;C12N9/02;(IPC1-7):A61K48/00;C12N15/85 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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