| 发明名称 |
THERAPEUTIC QUINOLINE COMPOUNDS WITH 5-HT-ANTAGONISTIC PROPERTIES |
| 摘要 |
Provided herein is a compound having the formula (I), (R<sp>2</sp> is typically a tertiary nitrogen atom, being either alkyl-substituted or member of a heterocyclic ring; R<sp>7</sp> is typically a monocyclic or bicyclic aromatic ring or a heterocyclic ring) wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT<sb>1B</sb> and 5HT<sb>1D</sb> antagonists. |
| 申请公布号 |
WO03037872(A1) |
申请公布日期 |
2003.05.08 |
| 申请号 |
WO2002SE01989 |
申请日期 |
2002.11.01 |
| 申请人 |
ASTRAZENECA AB;CHAPDELAINE, MARC;DAVENPORT, TIMOTHY;HAEBERLEIN, MARKUS;HORCHLER, CAREY;MCCAULEY, JOHN;PIERSON, EDWARD;SOHN, DANIEL |
发明人 |
CHAPDELAINE, MARC;DAVENPORT, TIMOTHY;HAEBERLEIN, MARKUS;HORCHLER, CAREY;MCCAULEY, JOHN;PIERSON, EDWARD;SOHN, DANIEL |
| 分类号 |
C07D215/48;A61K31/496;A61K31/5377;A61K31/551;A61P1/00;A61P3/04;A61P5/00;A61P9/00;A61P15/00;A61P15/10;A61P21/02;A61P25/14;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P43/00;C07D207/14;C07D215/22;C07D215/233;C07D215/42;C07D241/04;C07D243/08;C07D265/30;C07D311/24;C07D401/04;C07D401/12;C07D401/14;C07D405/12;C07D405/14;C07D413/06;C07D413/14;C07D417/12;(IPC1-7):C07D215/42;A61K31/537 |
主分类号 |
C07D215/48 |
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