METHODS TO TREAT DIABETES AND RELATED CONDITIONS BASED ON POLYMORPHISMS IN THE TCF1 GENE

摘要

This invention relates to the use of the novel association between the 483 A >G single nucleotide polymorphism of the TCF1 gene and the clinical response to glycemic control agents, such as DPPIV inhibitors, in patients with disorder s of glycemic control, especially diabetes and impaired glucose metabolism. Th is invention provides methods to classify patients for treatment and/or for optimization of clinical studies and to treat patients based on this association.