发明名称 |
HEPATITIS B VIRUS (HBV) ANTIGENIC POLYPEPTIDE-HEAT SHOCK PROTEIN COMPLEX AND USE THEREOF |
摘要 |
<p>The present invention provides a kind of HBV-antigen bound to heat shock proteins(hsps) which comprises core antigen, surface antigen and polymerase antigen. The present invention also provides a complex of HBV antigen bound to heat shock protein gp96 and hsp78, as well as a method for preparing the complex. The complex includes a complex of gp96 and hsp78 non-covalently bound to antigenic polypeptide, as well as a fusion protein of both which results from covalent binding. Such complex can be used to prepare therapeutic vaccine for treating hepatitis B and primary hepatocellular carcinoma.</p> |
申请公布号 |
EP1308462(A1) |
申请公布日期 |
2003.05.07 |
申请号 |
EP20010919092 |
申请日期 |
2001.02.27 |
申请人 |
INSTITUTE OF MICROBIOLOGY |
发明人 |
TIAN, BO;MENG, SONGDONG;GAO, GRORGE, F. |
分类号 |
A61K39/29;A61P1/16;A61P31/20;A61P35/00;C07K14/02;C07K14/47;C07K19/00;(IPC1-7):C07K19/00;C07K1/00 |
主分类号 |
A61K39/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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