| 摘要 |
There are described compounds of the formula: (see formula I) wherein R1 is aryl, or a group of the formula: (see formula II) wherein X is CH or N, and Z is 0 or N-R5 , in which R5 is hydrogen or lower alkyl, R2 is hydroxy or lower alkoxy, R3 is hydrogen or lower alkyl which may have suitable substituent(s), R4 is ar(lower)alkyl which may have suitable substituent(s), A is carbonyl or sulfonyl, and Y is bond or lower alkenylene, and pharmaceutically acceptable salt thereof, a process of producing same, pharmaceutical compositions containing them and the treatment of tachykinin mediated diseases with these compounds. These compounds are specially useful for treating respiratory diseases such as asthma, bronchitis, rhinitis, cough, expectoration, and the like; opthalmic diseases such as conjunctivitis, vernal conjunctivitis and the like; cutaneous diseases such as contact dermatitis, atopic dermatitis, urticaria, and other eczematoid dermatitis, and the like; inflammatory diseases such as rheumatoid arthritis, osteoarthritis, and the like; pains or aches (e. g., migraine, headache, toothache, cancerous pain, back pain, etc.); and the like in human being or animals.
|
