发明名称 |
PREPARATION AND USE OF FORMALIN-KILLED COLONIZATION-FACTOR-ANTIGEN (CFA)-EXPRESSING E. COLI ORGANISMS FOR VACCINATION AGAINST ENTERIC INFECTION/DIARRHEA CAUSED BY ENTEROTOXIGENIC E. COLI BACTERIA IN HUMANS |
摘要 |
Disclosed is a method of producing a vaccine composition against enteric infection caused by enterotoxigenic E. coli bacteria in humans. E. coli strains selected from different known strains each having the ability of expressing a certain type of colonization factor antigens are grown in a liquid culture medium. Finally formalin-killed E. coli strain having substantially preserved antigenic and hemagglutinating properties of said certain type of colonization factor antigens, is mixed with a pharmaceutically acceptable excipient and/or diluent. Further disclosed is a method of preventing an enteric infection caused by enterotoxigenic E. coli bacteria in humans, whereby a vaccine composition comprising inactivated E. coli strain is administered to a human being for the prevention of said infection.
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申请公布号 |
US6558678(B1) |
申请公布日期 |
2003.05.06 |
申请号 |
US19930108606 |
申请日期 |
1993.11.08 |
申请人 |
HOLMGREN JAN;SVENNERHOLM ANN-MARI |
发明人 |
HOLMGREN JAN;SVENNERHOLM ANN-MARI |
分类号 |
A61K39/02;A61K39/108;A61P31/04;A61P37/04;(IPC1-7):A61K39/108 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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