发明名称 |
Stem cell inhibitor |
摘要 |
The present invention provides a Stem Cell Inhibitor (SCI) protein which comprises at least one amino acid alteration from its native form which protein does not significantly aggregate but which retains substantially unaltered stem cell inhibitory activity. The alteration is preferably a conservative subsitution of a charged amino acid residue. Such proteins may be used in treating stem cells in a patient undergoing chemotherapy.
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申请公布号 |
US6558925(B2) |
申请公布日期 |
2003.05.06 |
申请号 |
US19980151450 |
申请日期 |
1998.09.11 |
申请人 |
WYETH |
发明人 |
GRAHAM GERARD;PRAGNELL IAN |
分类号 |
C12N15/09;A61K38/00;A61K38/22;A61P17/06;A61P35/00;A61P35/02;A61P39/00;A61P43/00;C07K14/47;C07K14/52;C12N1/21;C12N15/19;C12P21/02;(IPC1-7):C12P21/00;C12N15/00;A61K38/19 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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