| 摘要 |
<p>A mutation of the human apolipoprotein A-I comprising a leucine to proline variant in position 178, the corresponding nucleic acids, vectors, amino acid sequences and fragments thereof are disclosed. Methods for diagnosis and/or prognosis of cardiovascular diseases, especially hypoalphalipoproteinemia, relying on identification of the presence or absence of this Leu178∊Pro mutation. Methods for using the disclosure in the treatment of ApoA-1-linked diseases are also described.</p> |
