发明名称 |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
摘要 |
Pharmaceutical compositions that include an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
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申请公布号 |
US2003083232(A1) |
申请公布日期 |
2003.05.01 |
申请号 |
US20020235381 |
申请日期 |
2002.09.05 |
申请人 |
SOLTERO RICHARD;RADHAKRISHNAN BALASINGHAM;EKWURIBE NNOCHIRI N.;REHLANDER BRUCE;HICKEY ANTHONY;BOVET LI LI |
发明人 |
SOLTERO RICHARD;RADHAKRISHNAN BALASINGHAM;EKWURIBE NNOCHIRI N.;REHLANDER BRUCE;HICKEY ANTHONY;BOVET LI LI |
分类号 |
A61K47/48;(IPC1-7):A61K38/28;A61K31/56 |
主分类号 |
A61K47/48 |
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