A compound represented by the formula (I) [wherein Ar represents an optionally substituted cyclic group; X represents a bond or a spacer having a C<sb>1−6</sb> main chain; R<sp>1</sp> and R<sp>2</sp> are the same or different and each represents hydrogen or an optionally substituted hydrocarbon group or R<sp>1</sp> and R<sp>2</sp> may form an optionally substituted nitrogenous heterocycle in cooperation with the adjacent nitrogen atom; Y represents an optionally substituted divalent hydrocarbon group (excluding CO); R<sp>3</sp> represents hydrogen or an optionally substituted hydrocarbon group; and ring A and ring B each may have other substituent(s), and when ring B has another substituent, then this substituent may be bonded to R<sp>1</sp> to form a ring]; a salt of the compound; or a prodrug of any of these. They have antagonistic activity against a melanin−concentrating hormone and hence are useful as an obesity preventive/remedy, etc.
申请公布号
WO03035624(A1)
申请公布日期
2003.05.01
申请号
WO2002JP11045
申请日期
2002.10.24
申请人
TAKEDA CHEMICAL INDUSTRIES, LTD.;ISHIHARA, YUJI;KAMATA, MAKOTO;TAKEKAWA, SHIRO;SUZUKI, NOBUHIRO;KATO, KOKI
发明人
ISHIHARA, YUJI;KAMATA, MAKOTO;TAKEKAWA, SHIRO;SUZUKI, NOBUHIRO;KATO, KOKI