QUARTERNARY AMMONIUM COMPOUNDS AND THEIR USE AS ANTIMUSCARINIC AGENTS

摘要

Novel quaternary ammonium compounds of the formula (I) and any stereoisomers thereof, wherein, R1, R2, and R3 independently represent C1-C6 alkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R1, R2 and R3 may form a ring together with the quaternary ammonium nitrogen; R4 represents -H, -CH3, or -CO-R4-1, wherein R4-1 represents -(C1- C4 alkyl), -(C1-C4 alkoxy), or NR4-2R4-3, wherein R4-2 and R4-3 independently represent -H or -(C1-C4 alkyl); R5, R6 and R7 independently represent -H, - OCH3, -OH, -CONH2, -SO2NH2, -F, -Cl, -Br, -I, -CF3, or -(C1-C4 alkyl), optionally substituted with one or two -OH, -(C1-C4 alkoxy), -COOH, or -CO-O - (C1-C3 alkyl); and X represents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.