STEREOSELECTIVE MICROBIC REDUCTION OF ONE RACEMIC TETRALONE

摘要

The disclosed invention refers to the procedure for the performance of the following stereoselective reduction of one racemic tetralone and encompasses: bringing into contact the compound of the formula (I) with one microorganism or enzime system for reduction that is capable to perform the subject matter of reduction and that contains one enzime outcoming of the mentioned microorganism and one co-factor for the mentioned enzime and incubation of the obtained mixture under conditions sufficient to obtain (4R) tetralon of the formula (v) or hydrolite tetralone. Hydrolite tetralone can be used in the synthesis of sertraline. The subject matter of the invention further contains, if wanted, division of the (4S) tetralone of the formula (V) from (4R) tetralole of the formula (II). (4R) tetralole can then be oxidated in order to obtain compound of the formula (I), so the subject matter of the microbe reduction can be repeated in order to achieve more than the desired (4S) tetralone of the formula (V).