ADDITIVE CYTOPROTECTIVE EFFECTS OF TWO BIOACTIVE REGIONS OF PRO-OPIOMELANOCORTIN HORMONE

摘要

Computational analysis was used to define repetitive and bioactive regions o f the pro-opiomelanocortin SYSMEHFRWGKPV and YGGFM. Cytoprotection model of th e ethanol induced gastric lesion was used to prove the additive cytoprotective effects of the combination of sequences SYSMEHFRWGKPV and YGGFM, when compar ed to the individual peptid sequences. The combination of two sequences SYSMEHFRWGKPV and YGGFM is denoted KOMET and patented. The purpose of the administration of KOMET is to obtain better and stronger pharmacologic effec ts on the systemic and local modulation of the inflammation and wound healing. Additional structural formulas which represent different combinations of bot h sequences were also defined as: KOMET-1 with sequence YGGFMSYSMEHFRWGKPVYGGF M, KOMET-2 with sequence YGGFMSYSMEHFRWGKPV and KOMET-3 with sequence SYSMEHFRWGKPVYGGFM.